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Article

Genomic analysis drives tailored therapy in poor risk childhood leukemia.

Cancer cell - 14 Aug 2012

Harrison Christine J

Abstract excerpt

Ph-like acute lymphoblastic leukemia (ALL) is a novel subgroup of high-risk childhood ALL. In this issue of Cancer Cell, Roberts et al. describe the identification of genetic alterations that lead to activated kinase and cytokine receptor signaling in Ph-like ALL and demonstrate that this aberrant signaling can be inhibited effectively.

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Share to Genetic Predisposition to Disease
Share to Mutation
Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein-Tyrosine Kinases

Share to Receptors, Cytokine

Share to Signal Transduction

Source

Identifiers

PMID: 22897843
DOI: 10.1016/j.ccr.2012.07.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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