Article
A pathway-based gene signature correlates with therapeutic response in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2010
Zuo Zhuang, Jones Dan, Yao Hui, Thomas Deborah A, O'Brien Susan, Ravandi Farhad, Kantarjian Hagop M, Abruzzo Lynne V, Medeiros L Jeffrey, Chen Su S, Luthra Rajyalakshmi
Abstract excerpt
Biomarkers to predict response to therapy in adults with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) are not yet established. In this study, we performed a meta-analysis of earlier genome-wide gene expression studies to identify pathway-based genes that are associated with therapeutic response. The predictive power of these genes was validated by transcript profiling in diagnostic...
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