Article

A trispecific Ab directed to HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections

2022-08-12

Abstract excerpt

<title>Abstract</title> <p>The main barrier to HIV virus eradication is the presence of long-lived HIV-1 that persists in latent reservoirs. Current efforts have focused on HIV cure interventions that “shock and kill” virally infected cells to purge the latent pool. Latency reversing agents (LRAs) induce viral activation leading to immune cell recognition and clearance of latently-infected cells. Though several c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f36edbbd-7f7b-507f-8f61-3edd026ef8b9
DOI: 10.21203/rs.3.rs-1930540/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

A trispecific Ab directed to HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infectionsDOI 10.21203/rs.3.rs-1930540/v1Read

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaquesSemantic proximity Read

Insights into the HIV Latency and the Role of CytokinesSemantic proximity Read

Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV CureSemantic proximity Read

TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs <i>in vivo</i>Semantic proximity Read

The Use of Broadly Neutralizing Antibodies (bNAbs) in HIV-1 Treatment and PreventionSemantic proximity Read

Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirsSemantic proximity Read

Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?Semantic proximity Read

Sequential IL-15 and TGF-β1 stimulation expands reprogrammed CD103⁺CD39⁺ effector CD8⁺T cells and enhances HIV controlSemantic proximity Read

Bispecific antibodies: Potential immunotherapies for HIV treatmentSemantic proximity Read

The Current Status of Latency Reversing Agents for HIV-1 RemissionSemantic proximity Read

Targeting the latent human cytomegalovirus reservoir with virus specific nanobodiesSemantic proximity Read

The HIV latency reversal agent HODHBt enhances NK Cell effector and memory-like functions by increasing IL-15 mediated-STAT activationSemantic proximity Read