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Article

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2011

Benod Cindy, Vinogradova Maia V, Jouravel Natalia, Kim Grace E, Fletterick Robert J, Sablin Elena P

Abstract excerpt

An essential regulator of gene transcription, nuclear receptor liver receptor homologue 1 (LRH-1) controls cell differentiation in the developing pancreas and maintains cholesterol homeostasis in adults. Recent genome-wide association studies linked mutations in the LRH-1 gene and its up-stream regulatory regions to development of pancreatic cancer. In this work, we show that LRH-1 transcription is activated up...

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Share to Carcinoma, Pancreatic Ductal
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Gene Expression Regulation, Neoplastic

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Share to Pancreatic Neoplasms

Share to Receptors, Cytoplasmic and Nuclear

Share to RNA, Small Interfering

Source

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Identifiers

PMID: 21949357
DOI: 10.1073/pnas.1112047108
PMCID: PMC3193228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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