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Article

Death Receptor Activation-Induced Hepatocyte Apoptosis and Liver Injury

1 Sept 2003

Abstract excerpt

The TNFalpha receptor super-family consists of several members sharing a sequence homology in a unique function domain, the death domain, which is located in the intracellular portion of the receptor. These so-called death receptors, including Fas, TNF-R1 and TRAIL-R1/TRAIL-R2, are expressed on hepatocytes. When stimulated by their ligands, FasL, TNFalpha or TRAIL, respectively, the death receptors can activate...

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PMID: 14527081
DOI: 10.2174/1566524033479555

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