LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis

Abstract excerpt

BACKGROUND: The injured liver loses normal function, with concomitant decrease of key identity genes. Super-enhancers contribute to mammalian cell identity. Here, we identified core transcription factors (TFs) that are active in hepatocytes, using genome-wide analysis and hierarchical ordering of super-enhancer distribution. METHODS: Expression of core TFs was assessed in a cohort of patients with hepatitis or...

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