Article

Subventricular zone adult mouse neural stem cells and human glioblastoma stem cells require insulin receptor for self-renewal

2020-03-11

Abstract excerpt

<h4>Summary</h4> The insulin receptor (IR) is an evolutionarily conserved signaling protein that regulates development and cellular metabolism. IR signaling regulates neurogenesis in Drosophila ; however, a specific role for the IR in maintaining adult neural stem cells (NSCs) in mammals has not been investigated. We show that conditionally deleting the IR reduces adult NSCs of the subventricular zone by ∼70% ac...

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Literature Corpus work: f360754d-84c6-550c-9a3f-2fa0c4e31abf
DOI: 10.1101/2020.03.10.985598

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