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Article

Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells

20 Sept 2010

Abstract excerpt

A population of tumorigenic, chemoresistant, and radioresistant cancer stem cells is postulated to contribute to the aggressive and fatal clinical course of glioblastomas. Activation of the Hedgehog (HH) pathway and increased expression of its downstream effector GLI1 are driving factors of glioma tumorigenicity and glioma stem cell (GSC) biology. In this study, we describe a dependence of insulin-like growth...

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PMID: 20857406
DOI: 10.1002/jcp.22433

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