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The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells

1 Jan 2014

Abstract excerpt

Cancer cells frequently exploit the IGF signaling, a fundamental pathway mediating development, cell growth, and survival. As a consequence, several components of the IGF signaling are deregulated in cancer and sustain cancer progression. However, specific targeting of IGF-IR in humans has resulted efficacious only in small subsets of cancers, making researches wondering whether IGF system targeting is still...

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PMID: 24550888
DOI: 10.3389/fendo.2014.00010

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