Article

Multi-donor human cortical Chimeroids reveal individual susceptibility to neurotoxic triggers

2023-10-06

Abstract excerpt

Inter-individual genetic variation affects the susceptibility to and progression of many diseases. Efforts to study the molecular mechanisms mediating the impact of human genetic variation on normal development and disease phenotypes are limited, however, by the paucity of faithful cellular human models, and the difficulty of scaling current systems to represent multiple individuals. Here, we present human brain “...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f350d9e3-74f3-5465-8184-ced0abf5d03d
DOI: 10.1101/2023.10.05.558331

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-donor human cortical Chimeroids reveal individual susceptibility to neurotoxic triggersDOI 10.1101/2023.10.05.558331Read

Brain Chimeroids reveal individual susceptibility to neurotoxic triggers.Semantic proximity Read

Brain organoids and insights on human evolutionSemantic proximity Read

Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem CellsSemantic proximity Read

A phenotypic brain organoid atlas for neurodevelopmental disordersSemantic proximity Read

Optimization and scaling of patient-derived brain organoids uncovers deep phenotypes of diseaseSemantic proximity Read

Cerebral organoids to unravel the mechanisms underlying malformations of human cortical development.Semantic proximity Read

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.Semantic proximity Read

Modeling neurological disorders using brain organoids.Semantic proximity Read

Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolutionSemantic proximity Read

Benchmarking brain organoid recapitulation of fetal corticogenesisSemantic proximity Read

Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architectureSemantic proximity Read

A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders.Semantic proximity Read