Article
Brain Chimeroids reveal individual susceptibility to neurotoxic triggers.
Nature - 1 Jul 2024
Antón-Bolaños Noelia, Faravelli Irene, Faits Tyler, Andreadis Sophia, Kastli Rahel, Trattaro Sebastiano, Adiconis Xian, Wei Anqi, Sampath Kumar Abhishek, Di Bella Daniela J, Tegtmeyer Matthew, Nehme Ralda, Levin Joshua Z, Regev Aviv, Arlotta Paola
Abstract excerpt
Interindividual genetic variation affects the susceptibility to and progression of many diseases1,2. However, efforts to study how individual human brains differ in normal development and disease phenotypes are limited by the paucity of faithful cellular human models, and the difficulty of scaling current systems to represent multiple people. Here we present human brain Chimeroids, a highly reproducible,...
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