Article
24S-Hydroxycholesterol: A potential brain-derived biomarker of Huntington’s Disease
2025-10-09
Abstract excerpt
Huntington’s disease (HD) arises from of an expanded polyglutamine-coding trinucleotide repeat in exon 1 of the huntingtin gene. Despite considerable research, a successful disease modifying therapy has yet to be confirmed. Cholesterol homeostasis in brain is considered one of the biological processes to be disturbed in HD. In the current study we have shown, using liquid chromatography – mass spectrometry with mu...
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Identifiers and source
- Literature Corpus work
- f33ae849-566d-5604-be71-bcb0fb7f249a
- DOI
- 10.1101/2025.10.08.25337337