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Article

Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression.

PloS one - 25 Jul 2007

Mochel Fanny, Charles Perrine, Seguin François, Barritault Julie, Coussieu Christiane, Perin Laurence, Le Bouc Yves, Gervais Christiane, Carcelain Guislaine, Vassault Anne, Feingold Josué, Rabier Daniel, Durr Alexandra

Abstract excerpt

Huntington disease (HD) is a fatal neurodegenerative disorder, with no effective treatment. The pathogenic mechanisms underlying HD has not been elucidated, but weight loss, associated with chorea and cognitive decline, is a characteristic feature of the disease that is accessible to investigatio...

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Identifiers

PMID: 17653274
DOI: 10.1371/journal.pone.0000647
PMCID: PMC1919424

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17653274-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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