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Article

Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers.

Scientific reports - 22 Feb 2017

Skene Debra J, Middleton Benita, Fraser Cara K, Pennings Jeroen L A, Kuchel Timothy R, Rudiger Skye R, Bawden C Simon, Morton A Jennifer

Abstract excerpt

The pronounced cachexia (unexplained wasting) seen in Huntington's disease (HD) patients suggests that metabolic dysregulation plays a role in HD pathogenesis, although evidence of metabolic abnormalities in HD patients is inconsistent. We performed metabolic profiling of plasma from presymptomatic HD transgenic and control sheep. Metabolites were quantified in sequential plasma samples taken over a 25 h period...

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Identifiers

PMID: 28223686
DOI: 10.1038/srep43030
PMCID: PMC5320451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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