Article

Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites

2023-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Adjuvants have been essential to malaria vaccine development, but their impact on the vaccine-induced antibody repertoire is poorly understood. Here, we used cDNA sequences from antigen-specific single memory B cells to express 132 recombinant human anti-Pfs230 monoclonal antibodies (mAbs). Alhydrogel®-induced mAbs demonstrated higher binding to Pfs230D1, although functional activity was similar...

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Literature Corpus work: 236320e3-0c95-5ff3-ae1a-56f2ea392980
DOI: 10.1101/2023.08.01.551554

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