Article

Human interferon stimulated genes target ancient features of animal and bacterial viral replication

2026-06-12

Abstract excerpt

Animal and bacterial cells defend against viral infection by rapidly activating antiviral restriction factors. In human cells, antiviral immunity is initiated by interferon signaling that results in expression of hundreds of interferon-stimulated genes (ISGs) 1,2,3,4,5,6 . Complex regulatory networks and co-evolution of viral evasion strategies complicate analysis of immune proteins under native conditions and th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f30aa4c5-0d28-5472-a6f0-872ddfe90583
DOI: 10.64898/2026.06.11.731453

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human interferon stimulated genes target ancient features of animal and bacterial viral replicationDOI 10.64898/2026.06.11.731453Read

Bacterial and human exonucleases mediate interkingdom antiviral immunitySemantic proximity Read

Interferon-Stimulated Genes: What Do They All Do?Semantic proximity Read

Bacterial effector screening reveals RNF214 as a virus restriction factor in mammalsSemantic proximity Read

Interferon-stimulated genes: roles in viral pathogenesisSemantic proximity Read

IRF-1, RIG-I and MDA5 display potent antiviral activities against norovirus coordinately induced by different types of interferonsSemantic proximity Read

Interferon Lambda Genetics and Biology in Regulation of Viral ControlSemantic proximity Read

A Virus-Packageable CRISPR Screen Identifies Host Factors Mediating Interferon Inhibition of HIVSemantic proximity Read

Conservation of antiviral systems across domains of life reveals novel immune mechanisms in humansSemantic proximity Read

Evolution of the interferon response: lessons from ISGs of diverse mammalsSemantic proximity Read

Antagonizing the SAMD9 pathway is key to myxoma virus host shut-off and immune evasionSemantic proximity Read

Conservation of antiviral systems across domains of life reveals immune genes in humansSemantic proximity Read

Recent advances in antiviral interferon-stimulated gene biologySemantic proximity Read