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Antagonizing the SAMD9 pathway is key to myxoma virus host shut-off and immune evasion

2024-02-02

Abstract excerpt

Poxviruses have life cycles exclusively in the cytoplasm. However, these viruses can have profound impact to host transcription. One possible mechanism is through viral manipulation of host protein synthesis and such ability is critical for viral immune evasion. Many mammalian poxviruses encode more than one viral protein to interact with the host SAMD9 protein. In myxoma virus (MYXV), a rabbit specific poxvirus a...

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Identifiers and source

Literature Corpus work
19c16749-74ed-5db7-864d-d1f2daa761d7
DOI
10.1101/2024.02.01.578447
Open publication

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