Article

Identification of <i>cis</i> -regulatory mutations generating <i>de novo</i> edges in personalized cancer gene regulatory networks

2017-04-25

Abstract excerpt

The identification of functional non-coding mutations is a key challenge in the field of genomics, where whole-genome re-sequencing can swiftly generate a set of all genomic variants in a sample, such as a tumor biopsy. The size of the human regulatory landscape places a challenge on finding recurrent cis -regulatory mutations across samples of the same cancer type. Therefore, powerful computational approaches ar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f30954f9-e443-5d88-beb1-da1de761825c
DOI: 10.1101/130641

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of <i>cis</i> -regulatory mutations generating <i>de novo</i> edges in personalized cancer gene regulatory networksDOI 10.1101/130641Read

Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks.Semantic proximity Read

Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X.Semantic proximity Read

Candidate cancer driver mutations in superenhancers and long-range chromatin interaction networksSemantic proximity Read

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of the gene regulatory program in cancersSemantic proximity Read

A catalog of <i>cis</i> -regulatory mutations in 12 major cancer typesSemantic proximity Read

Assessing the Gene Regulatory Landscape in 1,188 Human TumorsSemantic proximity Read

Motif Disruption Domains Lead To Cancer Gene Expression RewiringSemantic proximity Read

Pathway and network analysis of more than 2500 whole cancer genomes.Semantic proximity Read

Non-coding mutations reveal cancer driver cistromes in luminal breast cancerSemantic proximity Read

Transcription Factor-Centric Approach to Identify Non-Recurring Putative Regulatory Drivers in CancerSemantic proximity Read

Recurrent somatic mutations in regulatory regions of human cancer genomes.Semantic proximity Read

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers.Semantic proximity Read