Article
Pathway and network analysis of more than 2500 whole cancer genomes.
Nature communications - 5 Feb 2020
Reyna Matthew A, Haan David, Paczkowska Marta, Verbeke Lieven P C, Vazquez Miguel, Kahraman Abdullah, Pulido-Tamayo Sergio, Barenboim Jonathan, Wadi Lina, Dhingra Priyanka, Shrestha Raunak, Getz Gad, Lawrence Michael S, Pedersen Jakob Skou, Rubin Mark A, Wheeler David A, Brunak Søren, Izarzugaza Jose M G, Khurana Ekta, Marchal Kathleen, von Mering Christian, Sahinalp S Cenk, Valencia Alfonso, Reimand Jüri, Stuart Joshua M, Raphael Benjamin J
Abstract excerpt
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing...
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