Article
Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks.
Genome medicine - 30 Aug 2017
Kalender Atak Zeynep, Imrichova Hana, Svetlichnyy Dmitry, Hulselmans Gert, Christiaens Valerie, Reumers Joke, Ceulemans Hugo, Aerts Stein
Abstract excerpt
The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative effect on the underlying "personal" gene regulatory network. We validated μ-cisTarget by re-analyzing the TAL1 and LMO1 enhancer mutations in T-ALL, and the TERT promoter mutation in melanoma. Next, we...
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