Article

Interconnection between molecular regulators in LMNA related muscular dystrophy

2022-03-10

Abstract excerpt

Nuclear lamina is composed of different A-type and B-type lamin proteins and acts as major regulator of DNA replication, transcription, heterochromatin-euchromatin machinery. The majority of mutations in A type lamin are associated with some forms of muscular dystrophies,that majorly distinguishable by a common clinical feature : progressive skeletal muscle wasting. This speculates impaired skeletal muscle differe...

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Literature Corpus work: f2dd45f3-a218-504d-88f8-bef23e4ac47e
DOI: 10.1101/2022.03.09.483617

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