Article
Remodelling of the nuclear lamina and nucleoskeleton is required for skeletal muscle differentiation in vitro.
Journal of cell science - 15 Jan 2005
Markiewicz Ewa, Ledran Maria, Hutchison Christopher J
Abstract excerpt
Changes in the expression and distribution of nuclear lamins were investigated during C2C12 myoblast differentiation. The expression of most lamins was unchanged during myogenesis. By contrast, lamin-B2 expression increased and LAP2alpha expression decreased twofold. These changes were correlated with reduced solubility and redistribution of A-type lamins. When C2C12 myoblasts were transfected with a lamin-A...
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