Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation.

Abstract excerpt

Mutations within LMNA, encoding A-type nuclear lamins, are associated with multiple tissue-specific diseases, including Emery-Dreifuss (EDMD2/3) and Limb-Girdle muscular dystrophy (LGMD1B). X-linked EDMD results from mutations in emerin, a lamin A-associated protein. The mechanisms through which these mutations cause muscular dystrophy are not understood. Here we show that most, but not all, cultured muscle cells...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blotting, Western
• Share to Desmin
• Share to Lamin Type A