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Article

SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells.

Scientific reports - 4 Apr 2018

Janin Alexandre, Bauer Delphine, Ratti Francesca, Valla Camille, Bertrand Anne, Christin Emilie, Chopin Emilie, Streichenberger Nathalie, Bonne Gisèle, Gache Vincent, Cohen Tatiana, Méjat Alexandre

Abstract excerpt

LMNA gene encodes lamins A and C, two major components of the nuclear lamina, a network of intermediate filaments underlying the inner nuclear membrane. Most of LMNA mutations are associated with cardiac and/or skeletal muscles defects. Muscle laminopathies include Emery-Dreifuss Muscular Dystrophy, Limb-Girdle Muscular Dystrophy 1B, LMNA-related Congenital Muscular Dystrophy and Dilated Cardiomyopathy with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29618840
DOI: 10.1038/s41598-018-23918-x
PMCID: PMC5884786

Genes

LMNA
BMP4
SMAD6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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