Article

Increased HIF-1α Expression in T Cells and Associated with Enhanced Th17 Pathway in Systemic Lupus Erythematosus

2021-12-01

Abstract excerpt

<title>Abstract</title> <p>Recent emerging evidences indicate that dysfunction of metabolic remodeling underlies aberrant T cell immune responses in systemic lupus erythematosus (SLE). However, how these aberrant immune activation and metabolic dysfunction interact in lupus patients are not fully understood. This study was undertaken to investigate the expression of HIF-1α, a regulator of metabolic reprogramming,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2b44382-6b3a-5cd1-9cdb-6a7d8e957edc
DOI: 10.21203/rs.3.rs-1101690/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased HIF-1α Expression in T Cells and Associated with Enhanced Th17 Pathway in Systemic Lupus ErythematosusDOI 10.21203/rs.3.rs-1101690/v1Read

Hypoxia‐inducible factor‐1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseasesSemantic proximity Read

Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cellsSemantic proximity Read

HIF1α-glycolysis engages activation-induced cell death to drive IFN-γ induction in hypoxic T cellsSemantic proximity Read

Human umbilical cord mesenchymal stem cells for the treatment of systemic lupus erythematosus via glucose metabolism of CD4 + T cellsSemantic proximity Read

Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupusSemantic proximity Read

Evidences for a protective role of vitamin D in COVID-19Semantic proximity Read

Potential roles of IL-1 subfamily members in glycolysis in diseaseSemantic proximity Read

Recent advances in understanding the molecular mechanisms of the development and function of <scp>T</scp>h17 cellsSemantic proximity Read

Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.Semantic proximity Read

NF ‐κB and HIF crosstalk in immune responsesSemantic proximity Read

Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia.Semantic proximity Read

HIF1α-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi’s Sarcoma-Associated HerpesvirusSemantic proximity Read