Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia.

PLoS pathogens - 1 May 2018

Singh Rajnish Kumar, Lang Fengchao, Pei Yonggang, Jha Hem Chandra, Robertson Erle S

Abstract excerpt

Kaposi's sarcoma associated herpesvirus (KSHV) infection stabilizes hypoxia inducible factors (HIFs). The interaction between KSHV encoded factors and HIFs plays a critical role in KSHV latency, reactivation and associated disease phenotypes. Besides modulation of large-scale signaling, KSHV infection also reprograms the metabolic activity of infected cells. However, the mechanism and cellular pathways modulated...

Topics

Join the communities discussing this publication.

Gene Expression Regulation, Viral
Herpesvirus 8, Human
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit
Lactic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 29746587
DOI: 10.1371/journal.ppat.1007062
PMCID: PMC5963815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia.PMID 29746587Read ↗

HIF1α-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi’s Sarcoma-Associated HerpesvirusSemantic proximity Read ↗

RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression SignatureSemantic proximity Read ↗

Hypoxia and hypoxia‐inducible factors in Kaposi sarcoma‐associated herpesvirus infection and disease pathogenesisSemantic proximity Read ↗

Kaposi's Sarcoma Herpesvirus MicroRNAs Induce Metabolic Transformation of Infected CellsSemantic proximity Read ↗

An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing GlycolysisSemantic proximity Read ↗

KSHV Reprogramming of Host Energy Metabolism for PathogenesisSemantic proximity Read ↗

RNA-Seq of Kaposi’s sarcoma reveals alterations in glucose and lipid metabolismSemantic proximity Read ↗

Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infectionSemantic proximity Read ↗

Hypoxia and HIF-1α promote lytic de novo KSHV infectionSemantic proximity Read ↗

Hypoxia-inducible factor 1 and its role in viral carcinogenesisSemantic proximity Read ↗

Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAsSemantic proximity Read ↗

Inhibition of KAP1 Enhances Hypoxia-Induced Kaposi's Sarcoma-Associated Herpesvirus Reactivation through RBP-JκSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.