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Integrative analysis of cfDNA features from ultra-low coverage whole genome sequencing enables robust detection of ovarian cancer

2026-07-04

Abstract excerpt

<h4>Background</h4> Despite advances in circulating tumor DNA analysis, reliable detection of oncological disease from ultra-low coverage whole genome sequencing (ulcWGS) remains challenging, particularly at low tumor fractions. This study leverages cell-free DNA (cfDNA) characteristics to develop and evaluate a robust, integrative binary predictive model for ovarian cancer (OC) status screening. OC represents a...

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Literature Corpus work: f2a85c9f-af27-5cfc-84b8-ac7be129428d
DOI: 10.64898/2026.07.02.26357095

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