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<i>In vitro</i> effects of S-Licarbazepine as a potential precision therapy on <i>SCN8A</i> variants causing neuropsychiatric disorders

2021-04-26

Abstract excerpt

<h4>Background and Purpose</h4> Among genetic epilepsies, variants in sodium channel coding genes constitute a major subgroup. Variants in SCN8A , the coding gene for Na V 1.6 channels, are characterized by a variety of symptoms including intractable epileptic seizures, psychomotor delay, progressive cognitive decline, and others such as autistic features, ataxia or dystonia. Standard anticonvulsant treatment h...

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Literature Corpus work
3158da95-a86e-5295-bfeb-28c51eb08fbe
DOI
10.1101/2021.04.24.441205
Open publication

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<i>In vitro</i> effects of S-Licarbazepine as a potential precision therapy on <i>SCN8A</i> variants causing neuropsychiatric disordersDOI 10.1101/2021.04.24.441205
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