Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional and structural characterization of PKA-mediated pHi gating of ROMK1 channels.

Journal of molecular graphics & modelling - 1 Oct 2008

Lee Chien-Hsing, Huang Po-Tsang, Lou Kuo-Long, Liou Horng-Huei

Abstract excerpt

Hyperprostaglandin E syndrome/antenatal Bartter syndrome (HPS/aBS) is a severe salt-losing renal tubular disorder and results from the mutation of renal outer medullary K(+) (ROMK1) channels. The aberrant ROMK1 function induces alterations in intracellular pH (pH(i)) gating under physiological conditions. We investigate the role of protein kinase A (PKA) in the pH(i) gating of ROMK1 channels. Using giant patch...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP-Dependent Protein Kinases
Share to Intracellular Space

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Mutant Proteins

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Potassium Channels, Inwardly Rectifying

Share to Sequence Analysis, Protein

Share to Xenopus laevis

Source

Identifiers

PMID: 18620882
DOI: 10.1016/j.jmgm.2008.06.001

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional and structural characterization of PKA-mediated pHi gating of ROMK1 channels.PMID 18620882Read ↗

A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.Semantic proximity Read ↗

Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP2 regulated pHi-gating.Semantic proximity Read ↗

pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.Semantic proximity Read ↗

Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.Semantic proximity Read ↗

Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation.Semantic proximity Read ↗

pH-dependent modulation of the cloned renal K+ channel, ROMK.Semantic proximity Read ↗

Computational investigation of mechanisms for pH modulation of human chloride channelsSemantic proximity Read ↗

Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.Semantic proximity Read ↗

Molecular and Functional Profiling of Gαi as an Intracellular pH SensorSemantic proximity Read ↗

Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity.Semantic proximity Read ↗

Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism.Semantic proximity Read ↗

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.