Article

Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function and thrombosis

2022-05-30

Abstract excerpt

The tyrosine kinase BTK plays an important role in platelet function downstream of GPVI and CLEC2 receptors and has been proposed as a novel target to prevent thrombosis in patients that are at increased risk. However, current clinically approved BTK inhibitors have off target effects and are associated with an increased bleeding risk. In this study, we therefore explored whether BTK can be targeted for degradatio...

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Literature Corpus work: f25ecb7d-1025-5c39-b3e5-49592e657833
DOI: 10.1101/2022.05.30.493973

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