Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line.

Scientific reports - 10 Apr 2017

Lau Chung-Ho E, Tredwell Gregory D, Ellis James K, Lam Eric W-F, Keun Hector C

Abstract excerpt

Somatic mutations in PIK3CA are frequently found in a number of human cancers, including breast cancer, altering cellular physiology and tumour sensitivity to chemotherapy. This renders PIK3CA an attractive molecular target for early detection and personalised therapy. Using 1H Nuclear Magnetic Resonance spectroscopy (NMR) and Gas Chromatography - Mass Spectrometery (GC-MS) together with 13C stable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Citric Acid Cycle
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Metabolome

Share to Metabolomics

Share to Proton Magnetic Resonance Spectroscopy

Share to Pyruvates

Source

Open in PubMed Open full text

Identifiers

PMID: 28393905
DOI: 10.1038/srep46079
PMCID: PMC5385542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line.PMID 28393905Read ↗

Exploring novel aspects of choline phospholipid metabolism in cancer using metabolomicsSemantic proximity Read ↗

Multiple metabolic alterations exist in mutant PI3K cancers, but only glucose is essential as a nutrient source.Semantic proximity Read ↗

Multiomics Integration Elucidates Metabolic Modulators of Drug Resistance in LymphomaSemantic proximity Read ↗

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolismSemantic proximity Read ↗

Integration of Metabolomics and Gene Expression Profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC-Diffuse Large B Cell LymphomaSemantic proximity Read ↗

Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transitionSemantic proximity Read ↗

PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.Semantic proximity Read ↗

Characterization of Lipid Alterations by Oncogenic PIK3CA Mutations Using Untargeted Lipidomics in Breast Cancer.Semantic proximity Read ↗

Mitochondrial ACSS1 regulates the oncometabolite 2-hydroxyglutarate and De Novo Pyrimidine biosynthesis under nutrient-deprived conditions in lymphomaSemantic proximity Read ↗

NMR metabolomics highlights sphingosine kinase‐1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cellsSemantic proximity Read ↗

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.Semantic proximity Read ↗

Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.