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Article

Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK.

Journal of cancer research and clinical oncology - 1 Feb 2010

Schmidt Melanie, Voelker Hans-Ullrich, Kapp Michaela, Krockenberger Mathias, Dietl Johannes, Kammerer Ulrike

Abstract excerpt

PURPOSE: Metabolic dependence on glucose utilisation has been described for different tumours characterised by activation of Akt, upregulation of GLUT1, M2PK and TKTL1. To date, however, little is known about glucose metabolism in breast cancer tissue. METHODS: We analysed 55 breast cancer specimens, 26 adjacent ductal carcinomas in situ (DCIS) and 23 adjacent normal breast tissues for expression of glycolytic...

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Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Transporter Type 1

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Share to Pyruvate Kinase

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Source

Identifiers

PMID: 19655166
DOI: 10.1007/s00432-009-0652-y

Genes

TKTL1

Provenance

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