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Cross-Species and Tissue-Agnostic Prediction of Human Cancer Treatment Response using AI-Powered Cellular Morphometric Biomarkers from a Genetically Diverse Erbb2 Mouse Model

2025-09-15

Abstract excerpt

The success of drug development relies heavily on the use of animal models. However, increasing evidence shows that discoveries in these models often fail to translate to human patients. In this study, we developed an AI framework to discovery cross-species and tissue-agnostic cellular morphometric biomarkers (CMBs) as a new avenue to improve translatability. Using this framework, we identified CMBs and CMB tumor...

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Literature Corpus work
f249443c-900e-5fb5-8f22-225fd2f3d727
DOI
10.1101/2025.09.15.25335730
Open publication

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Cross-Species and Tissue-Agnostic Prediction of Human Cancer Treatment Response using AI-Powered Cellular Morphometric Biomarkers from a Genetically Diverse Erbb2 Mouse ModelDOI 10.1101/2025.09.15.25335730
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