Article
Evaluating the transcriptional fidelity of cancer models
2020-03-29
Abstract excerpt
<h4>ABSTRACT</h4> <h4>Background</h4> Cancer researchers use cell lines, patient derived xenografts, engineered mice, and tumoroids as models to investigate tumor biology and to identify therapies. The generalizability and power of a model derives from the fidelity with which it represents the tumor type under investigation, however, the extent to which this is true is often unclear. The preponderance of models...
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Identifiers and source
- Literature Corpus work
- 6e9477d8-b974-5c3c-af4e-3e4fcc3ebe2f
- DOI
- 10.1101/2020.03.27.012757