Article

Expanding discovery from cancer genomes by integrating protein network analyses with in vivo tumorigenesis assays

2017-06-19

Abstract excerpt

Approaches that integrate molecular network information and tumor genome data could complement gene-based statistical tests to identify likely new cancer genes, but are challenging to validate at scale and their predictive value remains unclear. We developed a robust statistic (NetSig) that integrates protein interaction networks and data from 4,742 tumor exomes and used it to accurately classify known driver gene...

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Literature Corpus work: e544419c-e8b0-54cf-8258-ffa711e318f6
DOI: 10.1101/151977

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