Article

Overcoming Resistance to BRAF <sup>V600E</sup> Inhibition in Melanoma by Deciphering and Targeting Personalized Protein Network Alterations

2020-11-03

Abstract excerpt

BRAF V600E melanoma patients, despite initially responding to the clinically prescribed anti-BRAF V600E therapy, often relapse and their tumors develop drug resistance. While it is widely accepted that these tumors are originally driven by the BRAF V600E mutation, they often eventually diverge and become supported by various signaling networks. Therefore, patient-specific altered signaling signatures should be...

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Literature Corpus work: f228d20f-356a-5ef9-a8b5-4d76d6857792
DOI: 10.1101/2020.11.03.366245

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