Article

Multiobjective Optimization Identifies Cancer-Selective Combination Therapies

2020-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Combinatorial therapies are required to treat patients with advanced cancers that have become resistant to monotherapies through rewiring of redundant pathways. Due to a massive number of potential drug combinations, there is a need for systematic approaches to identify safe and effective combinations for each patient, using cost-effective methods. Here, we developed an exact multiobjective opti...

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Literature Corpus work: d6c7ae60-a2cb-5d35-a0f6-6eea3babf4b1
DOI: 10.1101/2020.04.10.035584

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