Article

A computational network approach to identify predictive biomarkers and therapeutic combinations for anti-PD-1 immunotherapy in cancer

2020-04-27

Abstract excerpt

<h4>Background</h4> Despite remarkable success, only a subset of cancer patients have shown benefit from the anti-PD1 therapy. Therefore, there is a growing need to identify predictive biomarkers and therapeutic combinations for improving the clinical efficacy. <h4>Results</h4> Based upon the hypothesis that aberrations of any gene that are close to MHC class I genes in the gene network are likely to deregulate...

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Literature Corpus work: 6e89ddac-b465-533b-8c63-9efa7fe4c162
DOI: 10.1101/2020.04.25.055616

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