Article
Diffusion mapping of drug targets on disease signaling network elements reveals drug combination strategies.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2018
Xu Jielin, Regan-Fendt Kelly, Deng Siyuan, Carson William E, Payne Philip R O, Li Fuhai
Abstract excerpt
The emergence of drug resistance to traditional chemotherapy and newer targeted therapies in cancer patients is a major clinical challenge. Reactivation of the same or compensatory signaling pathways is a common class of drug resistance mechanisms. Employing drug combinations that inhibit multiple modules of reactivated signaling pathways is a promising strategy to overcome and prevent the onset of drug...
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