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Article

ssMutPA: single-sample mutation-based pathway analysis approach for cancer precision medicine.

GigaScience - 2 Jan 2024

He Yalan, Lai Jiyin, Wang Qian, Pan Bingyue, Li Siyuan, Zhao Xilong, Wang Ziyi, Zhang Yongbao, Tang Yujie, Han Junwei

Abstract excerpt

BACKGROUND: Single-sample pathway enrichment analysis is an effective approach for identifying cancer subtypes and pathway biomarkers, facilitating the development of precision medicine. However, the existing approaches focused on investigating the changes in gene expression levels but neglected somatic mutations, which play a crucial role in cancer development. FINDINGS: In this study, we proposed a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39704703
DOI: 10.1093/gigascience/giae105
PMCID: PMC11659979

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