Article

Investigating the role of N-terminal domain in phosphodiesterase 4B-inhibition by molecular dynamics simulation

2020-05-14

Abstract excerpt

Phosphodiesterase 4B (PDE4B) is a potential therapeutic target for the inflammatory respiratory diseases such as congestive obstructive pulmonary disease (COPD) and asthma. The sequence identity of ∼88% with its isoform PDE4D is the key barrier in developing selective PDE4B inhibitors which may help to overcome associated side effects. Despite high sequence identity, both isoforms differ in few residues present in...

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Literature Corpus work: f21cd127-fdb6-5233-877f-049d0f1b08b7
DOI: 10.1101/2020.05.12.090993

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