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Article

Structural basis for the catalytic mechanism of human phosphodiesterase 9.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2008

Liu Shenping, Mansour Mahmoud N, Dillman Keith S, Perez Jose R, Danley Dennis E, Aeed Paul A, Simons Samuel P, Lemotte Peter K, Menniti Frank S

Abstract excerpt

The phosphodiesterases (PDEs) are metal ion-dependent enzymes that regulate cellular signaling by metabolic inactivation of the ubiquitous second messengers cAMP and cGMP. In this role, the PDEs are involved in many biological and metabolic processes and are proven targets of successful drugs for the treatments of a wide range of diseases. However, because of the rapidity of the hydrolysis reaction, an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18757755
DOI: 10.1073/pnas.0708850105
PMCID: PMC2533186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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