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Article

Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2015

Cedervall Peder, Aulabaugh Ann, Geoghegan Kieran F, McLellan Thomas J, Pandit Jayvardhan

Abstract excerpt

Phosphodiesterase 4 (PDE4) is an essential contributor to intracellular signaling and an important drug target. The four members of this enzyme family (PDE4A to -D) are functional dimers in which each subunit contains two upstream conserved regions (UCR), UCR1 and -2, which precede the C-terminal catalytic domain. Alternative promoters, transcriptional start sites, and mRNA splicing lead to the existence of over...

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Identifiers

PMID: 25775568
DOI: 10.1073/pnas.1419906112
PMCID: PMC4378417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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