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Article

Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity.

Biochemistry - 2 Dec 2008

Wang Huanchen, Yan Zier, Yang Serena, Cai Jiwen, Robinson Howard, Ke Hengming

Abstract excerpt

Cyclic nucleotide phosphodiesterase-8 (PDE8) is a family of cAMP-specific enzymes and plays important roles in many biological processes, including T-cell activation, testosterone production, adrenocortical hyperplasia, and thyroid function. However, no PDE8 selective inhibitors are available for trial treatment of human diseases. Here we report kinetic properties of the highly active PDE8A1 catalytic domain...

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Identifiers

PMID: 18983167
DOI: 10.1021/bi801487x
PMCID: PMC2646200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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