Back to search

Article

A GIBAC-based selectivity strategy for the design of PDE5 inhibitors to minimize visual disturbances

2024-05-21

Abstract excerpt

Phosphodiesterase type 5 (PDE5) inhibitors are widely used in the treatment of various conditions, including erectile dysfunction and pulmonary hypertension. Despite their clinical efficacy, these drugs quite often cause visual disturbances due to off-target effects on Phosphodiesterase type 5 (PDE6) in the retina. This review explores the application of a general intermolecular binding affinity calculator (GIBAC)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
471ea8ac-ce8a-5afd-a5a8-d1b8ab4086ff
DOI
10.20944/preprints202405.1374.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A GIBAC-based selectivity strategy for the design of PDE5 inhibitors to minimize visual disturbancesDOI 10.20944/preprints202405.1374.v1
Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.Semantic proximity
Current application status and structure–activity relationship of selective and non-selective JAK inhibitors in diseasesSemantic proximity
VirtuousPocketome: A Computational Tool for Screening Protein-ligand Complexes to Identify Similar Binding SitesSemantic proximity
Investigating the role of N-terminal domain in phosphodiesterase 4B-inhibition by molecular dynamics simulationSemantic proximity
Structure-based redesigning of pentoxifylline analogs against selective phosphodiesterases to modulate sperm functional competence for assisted reproductive technologiesSemantic proximity
Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis.Semantic proximity
Structure-based virtual screening toward the discovery of novel inhibitors for impeding the protein-protein interaction between HIV-1 integrase and human lens epithelium-derived growth factor (LEDGF/p75)Semantic proximity
Allostery between Distant Structural Regions Dictates Selectivity in GPCR:G Protein Coupling.Semantic proximity
Molecular study of mechanisms of action of cilostazol on certain families of phosphodiesterasesSemantic proximity
The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis PigmentosaSemantic proximity
Exploring novel natural compound-based therapies for Duchenne muscular dystrophy management: insights from network pharmacology, QSAR modeling, molecular dynamics, and free energy calculationsSemantic proximity
Designing drugs and chemical probes with the dualsteric approach.Semantic proximity
Select a neighboring publication to make it the new centre.