The CDH1-160C>A polymorphism is a risk factor for colorectal cancer.

doi:10.1002/ijc.24542

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Article

The CDH1-160C>A polymorphism is a risk factor for colorectal cancer.

International journal of cancer - 1 Oct 2009

Pittman Alan M, Twiss Philip, Broderick Peter, Lubbe Steven, Chandler Ian, Penegar Steven, Houlston Richard S

Abstract excerpt

Part of the inherited susceptibility to colorectal cancer (CRC) is caused by the coinheritance of common low risk variants. E-cadherin (CDH1) has an established role in CRC; somatic inactivation of CDH1 is a common early event, and germline mutations can cause early-onset CRC. The -160C>A promoter variant (rs16260) of CDH1 has been reported to influence CDH1 transcription and thereby represents a strong candidate...

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PMID: 19569232
DOI: 10.1002/ijc.24542

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CDH1

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