Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease.

Gut - 1 Aug 2009

Muise A M, Walters T D, Glowacka W K, Griffiths A M, Ngan B-Y, Lan H, Xu W, Silverberg M S, Rotin D

Abstract excerpt

BACKGROUND: Patients with Crohn's disease have defects in intestinal epithelial permeability that are inadequately explained by known inflammatory bowel disease (IBD) susceptibility genes. E-cadherin (CDH1) plays a vital role in maintaining the integrity of the intestinal barrier and its cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Cell Line
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Epithelial Cells

Share to Intestinal Mucosa

Share to Linkage Disequilibrium

Share to Microscopy, Confocal

Source

Identifiers

PMID: 19398441
DOI: 10.1136/gut.2008.175117

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19398441-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease.PMID 19398441Read ↗

Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn diseaseSemantic proximity Read ↗

Role of CDH1 gene variants and E-cadherin localization in gastric mucosal cancerizationSemantic proximity Read ↗

The CDH1-160C>A polymorphism is a risk factor for colorectal cancer.Semantic proximity Read ↗

Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis.Semantic proximity Read ↗

Genes involved in the regulation of intestinal permeability and their role in ulcerative colitis.Semantic proximity Read ↗

HNF4α and CDH1 are associated with ulcerative colitis in a Dutch cohort.Semantic proximity Read ↗

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.Semantic proximity Read ↗

Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.