Article

Verapamil limits inflammation by restoring VGCC-driven epithelial Ca <sup>2+</sup> in models of cystic fibrosis

2025-10-14

Abstract excerpt

<h4>Rationale</h4> In cystic fibrosis (CF), caused by mutations in the CFTR gene, excessive neutrophilic inflammation drives lung damage and premature mortality. Current anti-inflammatory therapies have limited efficacy, partly due to an incomplete understanding of the mechanisms underlying CF-associated inflammation. Increased epithelial Ca²⁺ signaling has been implicated, but how CFTR dysfunction perturbs the...

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Literature Corpus work: f1dcfe92-2384-54d0-beb9-90c022613551
DOI: 10.1101/2025.10.12.681885

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