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Article

Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2018

Robledo-Avila Frank H, Ruiz-Rosado Juan de Dios, Brockman Kenneth L, Kopp Benjamin T, Amer Amal O, McCoy Karen, Bakaletz Lauren O, Partida-Sanchez Santiago

Abstract excerpt

Cystic fibrosis (CF), one of the most common human genetic diseases worldwide, is caused by a defect in the CF transmembrane conductance regulator (CFTR). Patients with CF are highly susceptible to infections caused by opportunistic pathogens (including Burkholderia cenocepacia), which induce excessive lung inflammation and lead to the eventual loss of pulmonary function. Abundant neutrophil recruitment into the...

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Identifiers

PMID: 30120123
DOI: 10.4049/jimmunol.1800076
PMCID: PMC6143431

Genes

CFTR

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