Article
Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene.
JCI insight - 11 Jan 2021
Xu Jie, Livraghi-Butrico Alessandra, Hou Xia, Rajagopalan Carthic, Zhang Jifeng, Song Jun, Jiang Hong, Wei Hong-Guang, Wang Hui, Bouhamdan Mohamad, Ruan Jinxue, Yang Dongshan, Qiu Yining, Xie Youming, Barrett Ronald, McClellan Sharon, Mou Hongmei, Wu Qingtian, Chen Xuequn, Rogers Troy D, Wilkinson Kristen J, Gilmore Rodney C, Esther Charles R, Zaman Khalequz, Liang Xiubin, Sobolic Michael, Hazlett Linda, Zhang Kezhong, Frizzell Raymond A, Gentzsch Martina, O'Neal Wanda K, Grubb Barbara R, Chen Y Eugene, Boucher Richard C, Sun Fei
Abstract excerpt
Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of CF rabbits, a model with a relatively long lifespan and affordable maintenance and care costs. CF rabbits supplemented solely with oral osmotic laxative had a median...
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